Endocrine Abstracts

Introduction: Acromegaly is associated with alterations of glucose metabolism. The effect of somatostatin analogues (SMS) and pegvisomant (PEG) on glucose metabolism is still argument of debate.Study design: The purpose of this historical-prospective study was to compare, in a cohort of 47 patients with active acromegaly, the effects of SMS and PEG alone or in combination on glucose metabolism. All subjects were evaluated at baseline and at least 6 month...

Hyperinsulinemia has been associated to an increased risk of colorectal cancer and adenomas, while higher serum 25-hydroxy vitamin D3 and folate seem to reduce the development of colonic lesions in general population. Acromegalic patients have an increased risk of colonic tumors and an association between higher fasting insulin levels and risk of colonic adenomas has been previously demonstrated. No data are available about the influence of vitamin D and folate-homocysteine le...

Prolactin-secreting (PRL) adenomas are about 40% of all pituitary adenomas. The most important clinical symptoms of PRL excess are gonadal and sexual dysfunction as a result of tumor expansion in patients with macroadenomas. Medical therapy of prolactinomas relies on the use of dopamine agonists which induce normalization of PRL levels and shrinkage of the tumor mass in the majority of patients. The present study evaluated whether doses of dopamine agonist inducing normalizati...

Introduction: AIT develops in 15–20% of patients receiving amiodarone. Patients with persistent thyrotoxicosis or those with instable cardiac function, may be candidate for thyroidectomy; however, thyrotoxicosis and underlying cardiovascular disease may increased surgical risk.Matherials and methods: We retrospectively selected 23 AIT patients treated with a total thyroidectomy, from January 2000 to December 2010 [19 men, 4 women; mean (+SD), age 61...